“Redefining skin resilience”: Shiseido introduces new ULTIMUNE Power Infusing Serum

The new ULTIMUNE Power Infusing Serum will be available in travel retail progressively this year
Prestige skincare brand SHISEIDO is redefining skin resilience with the new ULTIMUNE Power Infusing Serum, “a breakthrough in skin immunity research” built on over 30 years of scientific innovation.
Powered by SHISEIDO’s exclusive Power Fermented Camellia+ technology, this advanced formula strengthens skin’s innate defenses and slows the skin aging cycle.
Available in travel retail progressively, the fourth iteration of the cutting-edge SHISEIDO ULTIMUNE Power Infusing Serum will be available in Travel Retail Asia Pacific, Japan, and Europe from March, and in Travel Retail Middle East from July.
Building on SHISEIDO’s longstanding research in skin immunity, ULTIMUNE Power Infusing Serum works at the cellular level to support 30 million skin cells, fortifying the skin’s natural defenses and enhancing resilience over time.

The latest SHISEIDO ULTIMUNE Power Infusing Serum strengthens skin’s defenses and slows the skin aging cycle
At its core, the patented Power Fermented Camellia+ complex harnesses antioxidant-rich Camellia seed extract, bio-fermented through the traditional Japanese ki-koji5 process to amplify amino acids for superior skin defense. The Fermented Camellia Seed Extract helps the skin's immune cells eliminate old, damaged cells by increasing the protein CXCL97. This protein attracts special immune cells known as Memory T cells, which are crucial for removing aging cells from the skin, keeping it healthier and more youthful.
Beyond a new generation of the popular ULTIMUNE serum, this is also the world’s first Memory T cell anti-aging serum. This breakthrough formulation targets the root causes of aging, reinforcing the skin’s moisture barrier to combat dryness and visible signs of aging.
Philippe Lesné, President & CEO of Shiseido Travel Retail, commented, “Led by more than 150 years of Shiseido research and development, SHISEIDO continues to elevate the concept of Japanese beauty. As the expert in skin beauty in Asia, Shiseido Travel Retail understands evolving traveler desires for science-backed products with efficacy that enhance overall wellbeing. The brand-new SHISEIDO ULTIMUNE is the result of Shiseido’s leadership in skin immunity research over the past three decades, uncovering how skin defends, regenerates, and thrives.
“As we bring the world’s first Memory T cell anti-aging formula to travel retail, we remain committed to delivering research-led skincare that empowers travelers to explore the world.”
Retaining its signature rich-yet-dewy texture that absorbs effortlessly, the new formula also introduces Matsurika, a natural ingredient known for its calming properties. Infused with a delicate green floral fragrance and natural essential oils, it enhances the skincare ritual into a moment of relaxation, encouraging deep breaths that soothe the senses while reinforcing skin resilience.

The new SHISEIDO ULTIMUNE Power Infusing Serum will be available in 100ml bottles in travel retail.
Recognizing the evolving skincare needs of travelers, Shiseido Travel Retail is also incorporating the renewed ULTIMUNE into its traveler exclusive offerings, providing convenient and curated skincare solutions for travelers worldwide.
According to Shiseido Travel Retail, the new ULTIMUNE Power Infusing Serum delivers proven results. In consumer testing, 98% of users saw healthier, glowing skin after three days. After four weeks, 98% noticed a slowdown in skin aging, and after using one bottle, 99% felt their skin had become resistant to aging signs.
Clinical studies further validated its efficacy, showing an 11% slowdown in the skin aging cycle, along with improvements in smoothness (+18%), firmness (+27%) and translucent glow (+19%) in eight weeks.
Since its debut in 2014, SHISEIDO ULTIMUNE has remained a powerhouse in prestige skincare, continuously evolving to meet shifting consumer needs. Over the past decade, the serum has undergone three renewals, won 252 global beauty awards and remains a bestseller in 88 countries and regions.
Now, as longevity and slow-aging trends shape the future of beauty, SHISEIDO “reaffirms its leadership with a next-generation formula designed for modern skin resilience”.
As part of SHISEIDO’s commitment to sustainability, the new ULTIMUNE emphasizes respect for nature and minimizing waste, with consideration for the ecosystems where ingredients are sourced. As a result, almost every part of the camellia plant is utilized in the new ULTIMUNE, from petals to leaves and seeds. Over 91% of the ingredients in the new SHISEIDO ULTIMUNE are of natural origin.